Background: An accurate assessment of the extent of the disease and size of lesions is needed for appropriate therapy decisions of endo perio lesions. Cone-beam computed tomography (CBCT) imaging with less radiation and high spatial resolution can provide comprehensive evaluation of endo perio lesions.Materials and method: 71 teeth with endo perio lesions were assessed using CBCT. Periodontal bone defects were studied for pattern of bone loss (horizontal/vertical) along with bone loss levels (in mm) on mesial and distal sides in association with furcation involvement. The periapical lesions were studied for their prevalence and extent based on CBCT PAI SCORE.Results: Horizontal and vertical bone loss were detected in 54 teeth (76.1%) and 17 teeth (23.95%) respectively. Mean crestal bone loss levels (in mm) on mesial and distal were 4.80±3.21 and 5.74±3.91 respectively. The mean height, width and depth of furcation defects were 3.19±2.99, 1.94±0.98 and 4.44±1.92 (mm) respectively. Periapical lesions were recorded in 55 teeth (77.5%). CBCT PAI score of 5 was scored in 35 teeth with mean lesion diameter of 11.3±2.83 (mm). 16 teeth had a healthy periapical tissue with a score of 0 and 1.Conclusions: CBCT is a valuable diagnostic tool that can help in assessing endo perio lesions by providing morphometric measurements of periodontal bone defects and the extent of associated periapical lesions.