Abstract
Background
Primary cutaneous cluster of differentiation 30-positive (CD30+) T-cell lymphoproliferative
disorders are the second most common type of skin T-cell lymphoma. The lesions exhibit
an indolent course, with a morphology resembling high-grade T-cell lymphoma.
Case Description
A 67-year-old healthy man sought treatment for a large nonhealing ulcer on the buccal
gingiva of the mandibular right premolars. He reported a history of recurrent cutaneous
lesions, for which he was seen 1 year earlier at a hospital. Results of incisional
biopsy showed a dense lymphoid cell infiltrate composed of atypical CD30+ T-cells
intermixed with eosinophils. The diagnosis was updated to CD30+ T-cell lymphoproliferative
disorder, which was similar to the cutaneous lesion diagnosis. The lesion area healed
completely, and there were no signs of recurrence at 18-month follow-up.
Practical Implications
Oral CD30+ T-cell lymphoproliferative disorder has a favorable outcome, but it is
commonly misdiagnosed. Biopsy is crucial and should be combined with clinical examination
to avoid chemotherapeutic treatments intended for high-grade lymphoma.
Key Words
Oral CD30+ T-cell lymphoproliferative disorder
oral mucosa
oral ulceration
Abbreviation Key:
CD (Cluster of differeniation), EBER (Epstein-Barr virus-encoded small nuclear RNA), IHC (Immunohistochemistry), LyP (Lymphomatoid papulosis), NA (Not applicable), pcALCL (Primary cutaneous anaplastic large-cell lymphoma), pcCD30+ T-LPD (Primary cutaneous cluster of differentiation 30-positive T-cell lymphoproliferative
disorder), TCR (T-cell receptor)
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Biography
Dr. Nguyen is a dental student, Professional Program for International Dentists, Section of Periodontics, UCLA School of Dentistry, Los Angeles, CA.
Biography
Dr. Yaghsezian is a postgraduate resident, Section of Periodontics, UCLA School of Dentistry, Los Angeles, CA.
Biography
Dr. Lin is an associate professor, Section of Oral and Maxillofacial Pathology, UCLA School of Dentistry, Los Angeles, CA.
Biography
Dr. Klokkevold is a professor of clinical dentistry and residency program director, Section of Periodontics, UCLA School of Dentistry, Los Angeles, CA.
Article Info
Publication History
Published online: October 28, 2021
Publication stage
In Press Corrected Proof
Footnotes
Disclosure. None of the authors reported any disclosures.
The authors are grateful to all of the members of sections of periodontics and oral and maxillofacial pathology, UCLA School of Dentistry, for their help and support for the completion of the case.
Identification
DOI: https://doi.org/10.1016/j.adaj.2021.07.015
Copyright
(C) 2021 American Dental Association. All rights reserved.
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